Mathematically and experimentally defined porous bone scaffold produced for bone substitute application

Authors

  • Amirsalar Khandan New Technologies Research Center, Amirkabir University of Technology, Tehran 15875-4413, Iran
  • David Ogbemudia Mechanical Engineering Department, Eastern Mediterranean University, North Cyprus, Gazimağusa, TRNC, Mersin 10, Turkey
  • Hamed Joneidi Yekta New Technologies Research Center, Amirkabir University of Technology, Tehran 15875-4413, Iran
  • Maryam Shahali Department of Quality Control, Research and Production Complex, Pasteur Institute of Iran, Tehran, Iran
  • Saeed Saber Samandari New Technologies Research Center, Amirkabir University of Technology, Tehran 15875-4413, Iran
  • Siros Khorshidi New Technologies Research Center, Amirkabir University of Technology, Tehran 15875-4413, Iran
  • Soheila Rezaei Department of Molecular Genetic, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Abstract:

Objective (s): Artificial bone implants have been studied as a possible bone replacement for fractured and destroyed facial tissue; the techniques employed to determine the success of the dental implants. The stability, porosity and resistance of the bone implant which is subjected to varying forces and stresses within the surrounding bone is a subject of interest among the dentists. Materials and Methods: An experimental analysis was conducted on bio-nanocomposite scaffold using space holder methods. The reaction of the bio-nanocomposites deformation under load was determined using Abaqus software. Thereafter, an analytical solution was presented to express explicitly the deformation responses of the artificial bone implant. Results: It was seen that the vibrational behavior and mechanical performance of the sample containing 15 wt% additives have shown better mechanical characteristic compared to the pure specimen. On the other hand, the additive weight fraction has a significant effect on the compression test and porosity value. Also, the elastic modulus of the samples increases more than two times with the addition of additive (from 60 MPa to 145 MPa). From the results, it can be concluded that the highest vibration variation is seen in the sample with lower MNPs percentages.Conclusion: By observing the results of the stresses, it was seen that the stresses were in a small value in the bio-nanocomposites with highest amount of reinforcement.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Development of an antibacterial porous scaffold for bone defect treatment

Background & Aim: The use of bone scaffolds is one of the new and efficient techniques for repairing bone defects that provide a suitable platform for cell proliferation and growth to repair the target tissue. One of the most important causes of failure of transplants and surgical procedures is the invasion of bacteria at the site of the complication and the development of severe infection. The...

full text

Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering

Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. Highly porous titanium scaffolds, produced by selective laser sintering with mechanical properties in range of trabecular bone (compressive streng...

full text

Mathematically defined tissue engineering scaffold architectures prepared by stereolithography.

The technologies employed for the preparation of conventional tissue engineering scaffolds restrict the materials choice and the extent to which the architecture can be designed. Here we show the versatility of stereolithography with respect to materials and freedom of design. Porous scaffolds are designed with computer software and built with either a poly(D,L-lactide)-based resin or a poly(D,...

full text

A polycaprolactone bio-nanocomposite bone substitute fabricated for femoral fracture approaches: Molecular dynamic and micromechanical Investigation

The application of porous bio-nanocomposites polymer has greatly increased in the treatment of boneabnormalities and bone fracture. Therefore, predicting the mechanical properties of these bio-nanocompositesare very important prior to their fabrication. Investigation of mechanical properties like (elasticmodulus and hardness) is very costly and time-consuming in experimental t...

full text

Bone Substitute Effect on Vascularization and Bone Remodeling after Application of phVEGF165 Transfected BMSC

VEGF (vascular endothelial growth factor) promotes vascularization and remodeling of bone substitutes. The aim of this study was to examine the effect of distinct resorbable ceramic carriers on bone forming capacities of VEGF transfected bone marrow stromal cells (BMSC). A critical size defect of the radius in rabbits was filled either by a low surface scaffold called beta-TCP (tricalciumphspha...

full text

Comparative Study of Bone Repair Using Porous Hydroxyapatite/ β-Tricalcium Phosphate and Xenograft Scaffold in Rabbits with Tibia Defect

Background: Bone tissue engineering requires materials that are biocompatible, mechanically suited for bone function, integrated with the host skeleton, and support osteoinduction of the implanted cells for new bone formation. The aim of this study was to compare the osteogenic potential of xenograft with hydroxyapatite/β- tricalcium phosphate (HA/β-TCP) scaffold. Methods: New Zealand rabbits (...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 5  issue 4

pages  227- 234

publication date 2018-10-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023